abstract：BACKGROUND:Vaccination with 2 doses of > 95% of the population is necessary to eliminate measles. In Switzerland and especially in the central part, vaccine coverage is low (2006: 65%). This led 2006-2009 to a measles epidemic with thousands of cases and high costs. One death was noted in a formerly healthy 12 year old...

journal_title：Klinische Padiatrie

authors： Donas A,Marty-Nussbaumer A,Roost HP,Neuhaus TJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Lupus vulgaris (LV) is the most common form of cutaneous tuberculosis (TB) in Europe, nevertheless the overall incidence is low. It constitutes about 1.5% of all extra-pulmonary cases worldwide. A slight raise in TB incidence rates among children was recently registered in Germany, which can be explained by ...

journal_title：Klinische Padiatrie

authors： Striegel AK,Nazzal R,Fabri M,Rietschel E,Dötsch J,Mauch C,Tantcheva-Poor I

更新日期：2014-01-01 00:00:00

abstract：:Aim of this study was to describe the course of perinatal factors in neonates with meconium aspiration syndrome (MAS) from 1990 to 2010 and to determine risk factors for a severe course of the disease.All neonates with MAS hospitalized in our level III neonatal intensive care unit from 1990 to 2010.Retrospective analy...

journal_title：Klinische Padiatrie

authors： Hofer N,Jank K,Resch E,Urlesberger B,Reiterer F,Resch B

更新日期：2013-12-01 00:00:00

abstract：:In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare, some of the infections seen in immunodeficient patients are common. Defective antibod...

journal_title：Klinische Padiatrie

authors： Vancikova Z,Freiberger T,Vach W,Trojanek M,Rizzi M,Janda A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Anticonvulsants require special consideration particularly at the interface from hospital to ambulatory care. PATIENTS AND METHOD:Observational study for 6 months with prospectively enrolled consecutive patients in a neuropediatric ward of a university hospital (age 0-<18 years) with long-term therapy of at...

journal_title：Klinische Padiatrie

authors： Bertsche A,Dahse AJ,Neininger MP,Bernhard MK,Syrbe S,Frontini R,Kiess W,Merkenschlager A,Bertsche T

更新日期：2013-09-01 00:00:00

abstract：:Standard for diagnosis of inflammatory bowel disease (IBD) is the endoscopy of the stomach and the intestine. Aim of this study was to determine the value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in pediatric patients with mild to moderate IBD.We included 23 children and adolescents between 8 a...

journal_title：Klinische Padiatrie

authors： Berthold LD,Steiner D,Scholz D,Alzen G,Zimmer KP

更新日期：2013-07-01 00:00:00

abstract：:During the last 6 years 73 previously untreated children and adolescents with acute lymphoblastic leukemia were enrolled on a non-randomized therapy protocol. In this longitudinal study the specific accent was put on the intensified induction treatment of 8 weeks' duration which was thought to achieve a higher remissi...

journal_title：Klinische Padiatrie

authors： Riehm H,Gadner H,Welte K

更新日期：2013-05-01 00:00:00

abstract：:Between 1981 and 2000, 6 609 children (<18 years of age) were treated in 5 consecutive trials of the Berlin-Frankfurt-Münster (BFM) study group for childhood acute lymphoblastic leukemia (ALL). Patients were treated in up to 82 centers in Germany, Austria, and Switzerland. Probability of 10-year event-free survival (s...

journal_title：Klinische Padiatrie

authors： Schrappe M,Möricke A,Reiter A,Henze G,Welte K,Gadner H,Ludwig WD,Ritter J,Harbott J,Mann G,Klingebiel T,Gruhn B,Niemeyer C,Kremens B,Niggli F,Debatin KM,Ratei R,Stanulla M,Beier R,Cario G,Schrauder A,Zimmermann

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Gender differences in overall neonatal survival and in short term pulmonary outcome have been reported. Furthermore gender differences in childhood chronic lung disorders have been described all in favor of females. METHODS:A typical survey on published data regarding gender differences in lung development ...

journal_title：Klinische Padiatrie

authors： Gortner L,Shen J,Tutdibi E

更新日期：2013-03-01 00:00:00

abstract：:Members of the histone deacetylase (HDAC) family exhibit great promise as potential drug targets in pediatric tumors including neuroblastoma, medulloblastoma, ependymoma and Ewing's sarcoma. HDAC inhibitors of various structural classes have shown anti-tumoral effects in pre-clinical pediatric tumor models as single a...

journal_title：Klinische Padiatrie

authors： Witt O,Milde T,Deubzer HE,Oehme I,Witt R,Kulozik A,Eisenmenger A,Abel U,Karapanagiotou-Schenkel I

更新日期：2012-10-01 00:00:00

abstract：:Newly diagnosed immune thrombocytopenia occurs in 3-5/100 000 children < 14 y per year. Bleeding symptoms do not correlate with platelet count. Diagnostic approach includes history, clinical examination and analysis of blood count with blood smear by experienced hematologist. Additional investigations are only necessa...

journal_title：Klinische Padiatrie

authors： Eberl W,Dickerhoff R,Pediatric Committee of Society of Thrombosis and Hemostasis Research.

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Alcoholism during pregnancy is one of the most common factors in western societies causing persisting congenital and multiple physical as well as neurological impairments. Finding the diagnosis at first sight puts medical professionals into a demanding situation. Therefore the objective of this study was to ...

journal_title：Klinische Padiatrie

authors： Alex K,Feldmann R

更新日期：2012-03-01 00:00:00

abstract：:Aim of the present study was to test whether six-hour (6 h) urine specimens predict the 24-hour (24 h) mineral homeostasis in individual infants born preterm. Urinary Calcium (Ca) and Phosphate (P) concentrations were studied in 60 stable infants; gestational age 34 (25-42) weeks. In 58 infants four 6 h urine specimen...

journal_title：Klinische Padiatrie

authors： Mihatsch W,Trotter A,Pohlandt F

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Children with Epidermolysis bullosa (EB) suffer from an intractable, burdensome skin disease that may result in cognitive as well as social and emotional problems. PATIENTS:To assess cognitive problems in patients with EB, we investigated 20 affected children and adolescents, 6-17 years of age (mean: 10.8 y...

journal_title：Klinische Padiatrie

authors： Feldmann R,Weglage J,Frosch M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The considerable increase of obesity in children and adolescents poses a major challenge to the health care system. METHODS:In an observation study of the Bundeszentrale für gesundheitliche Aufklärung (BZgA) somatic data of 1916 overweight and obese children and adolescents aged 8-17 years were compared to ...

journal_title：Klinische Padiatrie

authors： Flechtner-Mors M,Thamm M,Rosario AS,Goldapp C,Hoffmeister U,Mann R,Bullinger M,van Egmond-Fröhlich A,Ravens-Sieberer U,Reinehr T,Westenhöfer J,Holl RW

更新日期：2011-12-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a heterogeneous group of congenital diseases characterized by their presentation with life threatening infections in the first months of life. The clinical presentation and the therapeutic outcome is influenced by multiple factors: the genetic defect, infectious complications...

journal_title：Klinische Padiatrie

authors： Hönig M,Schulz A,Friedrich W

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:Despite about 3 decades of clinical experience with the therapy of inherited thrombocytopathies (HTP) with desmopressin (DDAVP) the mechanisms of haemostatic effects of DDAVP in these diseases remain unclear. Therefore platelet function diagnostics was carried out in whole blood (WB) from children with aspir...

journal_title：Klinische Padiatrie

authors： Tauer JT,Gneuss A,Lohse JE,Jürgens T,Knöfler R

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:For Thrombasthenia Glanzmann (GT) patients presenting with a severe clinical phenotype due to complete lack of thrombocyte function or increased titres of anti-platelet antibodies hematopoietic stem cell transplantation (SCT) is the only curative therapy. CASE REPORT:We report the case of a 13-month-old boy...

journal_title：Klinische Padiatrie

authors： Wiegering V,Winkler B,Langhammer F,Wölfl M,Wirbelauer J,Sauer K,Kobsar A,Meyer T,Strauss A,Bakchoul T,Eyrich M,Schlegel PG

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The role for testis-sparing surgery in the treatment of primary intratesticular lesions in childhood is growing. The reliability of scrotal ultrasonograpy (US) in the management of these lesions is still controversial. PATIENTS:Between 1991 and 2007, 383 children and adolescents presented with testicular ab...

journal_title：Klinische Padiatrie

authors： Tallen G,Hernáiz Driever P,Degenhardt P,Henze G,Riebel T

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To investigate the change of psychological symptoms and quality of life in children and adolescents with congenital heart disease, cancer, or cystic fibrosis after a family-oriented inpatient rehabilitation program. METHODS:302 participants in the intervention (aged 4-17 years, mean=8.7) were assessed using ...

journal_title：Klinische Padiatrie

authors： Goldbeck L,Hölling I,Schlack R,West C,Besier T

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Currently there are 3 pneumococcal vaccines available in Germany. The aim of this study is to evaluate the potential of the three currently available pneumococcal vaccines to reduce the burden of invasive pneumococcal disease in children. SUBJECTS:Children younger than 16 years who have been hospitalized be...

journal_title：Klinische Padiatrie

authors： Rückinger S,van der Linden M,Siedler A,von Kries R

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Intrauterine growth restriction seems to be a risk factor for an aggravated course of secondary renal diseases in children. Catch-up growth after birth may play a critical role. We tested if there is an association between an aggravated course of nephritis in Henoch-Schönlein Purpura (PSHN) and low birth wei...

journal_title：Klinische Padiatrie

authors： Plank C,Vasilache I,Dittrich K,Dötsch J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Up to now, no German language test for children has been controlled for diagnostic accuracy. Therefore the application of language tests in clinical diagnostics is limited. The aim of the study was to determine the diagnostic validity of the SBE-3-KT, a parent questionnaire for identification of children wit...

journal_title：Klinische Padiatrie

authors： Tippelt S,Kademann S,von Suchodoletz W

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The survival of infants born with esophageal atresia (EA) is > 90% at present. The purpose of this study was to evaluate early complications and long term outcome in children with EA treated at our institution. METHODS AND PATIENTS:Retrospective analysis of 111 children with EA undergoing repair of EA or tr...

journal_title：Klinische Padiatrie

authors： Lacher M,Froehlich S,von Schweinitz D,Dietz HG

更新日期：2010-09-01 00:00:00

abstract：:Several randomized controlled trials (RCTs) have investigated the prophylactic use of probiotics in preterm infants aimed at reducing the rate of necrotising enterocolitis (NEC). There are 4 meta-analyses on this subject. 2 more RCTs have been published since these meta-analyses were completed. Each meta-analysis, as ...

journal_title：Klinische Padiatrie

authors： Guthmann F,Kluthe C,Bührer C

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate paediatric reference values for platelet function using a point-of-care whole blood impedance aggregometry. METHODS, RESULTS & CONCLUSION: In 265 healthy infants and children aged

journal_title：Klinische Padiatrie

authors： Halimeh S,Angelis Gd,Sander A,Edelbusch C,Rott H,Thedieck S,Mesters R,Schlegel N,Nowak-Göttl U

更新日期：2010-05-01 00:00:00

abstract：:Inherited disorders of platelets constitute a group of rare diseases that give rise to bleeding syndromes of variety severity, with more severe cases being first diagnosed during infancy and childhood. To appropriate diagnose a platelet function disorder during early childhood the knowledge of the physiological charac...

journal_title：Klinische Padiatrie

authors： Schlegel N,Bardet V,Kenet G,Muntean W,Zieger B,Nowak-Göttl U,Working Group on Standardisation in Perinatal and Pediatric Hemostasis.

更新日期：2010-05-01 00:00:00

abstract：:Bloody nipple discharge in adults is, in men as well as in women, often a symptom of an underlying malignant disease. In respect of this, multiple invasive and mutilating diagnostic procedures have been performed in infants and older children. Apart from individual cases in older and pubertal children, in childhood be...

journal_title：Klinische Padiatrie

authors： Harmsen S,Mayatepek E,Klee D,Meissner T

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The risk of severe complications or death during the initial period of acute leukemia was markedly decreased due to the progress in pediatric oncology and use of simple measures like hyperhydration, forced diuresis, treatment of hyperuricemia, correction of electrolyte and coagulation disturbances and the ca...

journal_title：Klinische Padiatrie

authors： Haase R,Merkel N,Diwan O,Elsner K,Kramm CM

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Congenital Central Hypoventilation Syndrome (CCHS, Ondine's curse) is a rare syndrome of dysfunction of the autonomic nervous system characterized by a decreased response to hypercarbia requiring mechanical ventilation in most cases. CCHS is an autosomal-dominant disease associated with tumors of neural cres...

journal_title：Klinische Padiatrie

authors： Hammel M,Klein M,Trips T,Priessmann H,Ankermann T,Holzinger A

更新日期：2009-09-01 00:00:00

abstract：:Growing teratoma is still an often unsolved problem especially in male with mixed malignant GCTs of the testis or the mediastinum. This specific situation with progressive tumor growth and simultaneous normalization of tumor markers during or after treatment of malignant GCTs with teratomatous elements is judged as a ...

journal_title：Klinische Padiatrie

authors： Calaminus G,Schneider DT,Weissbach L,Schönberger S,Okpanyi V,Leuschner I,Poremba C,Göbel U

更新日期：2009-05-01 00:00:00

abstract：:Dimenhydrinate overdosage in a 3(1/2) year-old-girl with dilative cardiomyopathy. Dimenhydrinate (Vomex(R)) is frequently used in the treatment of sickness and vomiting. The symptoms of overdosage present like an anticholinergic syndrome. We report on the clinical findings of an intoxication with dimenhydrinate in a 3...

journal_title：Klinische Padiatrie

authors： Girisch M,Hofbeck M,Rauch R,Apitz C,Sieverding L

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Empirical results about the cognitive, motor and psychic development in patients with d-transposition of the great arteries after arterial switch operation remain unclear. Potential reasons are the patients' initial status, improved perinatal care or the quality of surgery. To exclude quality of surgery as t...

journal_title：Klinische Padiatrie

authors： Vahsen N,Kavsek M,Toussaint-Götz N,Schneider K,Urban AE,Schneider M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:There is a subgroup of pediatric patients with an immature immunophenotype of proB-ALL that still poses a therapeutic challenge, even if the overall prognosis in B cell precursor acute lymphoblasic leukemia (BCP-ALL) is very good. Due to impaired treatment response these patients are prone to suffer relapse ...

journal_title：Klinische Padiatrie

authors： Troeger A,Glouchkova L,Escherich G,Siepermann M,Hanenberg H,Janka-Schaub G,Göbel U,Ackermann B,Dilloo D

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Spinal compression can be a complication of neuroblastoma (NBL). Delayed or insufficient treatment of this condition may lead to permanent neurological sequelae. Therefore, appropriate treatment should be introduced promptly. Therapeutic options include neurosurgery, chemotherapy, and radiation therapy. CAS...

journal_title：Klinische Padiatrie

authors： Walter KN,Kratz C,Uhl M,Niemeyer C

更新日期：2008-05-01 00:00:00

abstract：:Guillain Barré syndrome (GBS; Synonyma: Polyneuritis, Polyradikulitis) is an acute, inflammatory, demyelinating disease of the peripheral nerve system. Clinical hallmarks are symmetric muscle paralysis, areflexia and pronounced autonomic disturbances. Respiratory failure and cardiovascular instability are the main rea...

journal_title：Klinische Padiatrie

authors： Erler T,Weidner B,Wetzel U,Grunske A

更新日期：2008-03-01 00:00:00

abstract：UNLABELLED:We present an unusual case of neonatal liver failure. Isolated ascites was diagnosed in a female fetus at week 34 gestational age upon routine ultrasound. In the 35th week of gestation a cesarean section was carried out after puncture of fetal ascites. After birth the patient showed symptoms and complication...

journal_title：Klinische Padiatrie

authors： Keller M,Scholl-Buergi S,Sergi C,Theurl I,Weiss G,Unsinn KM,Trawöger R

更新日期：2008-01-01 00:00:00

abstract：:Neurofibromatosis type 1 is the most common of the phakomatoses and the clinical follow-up is an interdisciplinary challenge. The data of 27 patients with NF1 were systematically reviewed and compared to data from the literature. All of our patients had clinical signs of NF1. Besides the classic criteria café-au-lait ...

journal_title：Klinische Padiatrie

authors： Syrbe S,Eberle K,Strenge S,Bernhard MK,Herbertz S,Bierbach U,Hirsch W,Froster UG,Kiess W,Merkenschlager A

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Most recent studies analyzing candidate biological prognostic factors in childhood medulloblastoma (MB) are limited by small patient numbers due to dependence on fresh-frozen tumor material. By contrast, large archives of formalin-fixed, paraffin-embedded MB samples exist from homogeneously treated patients....

journal_title：Klinische Padiatrie

authors： Grotzer MA,von Hoff K,von Bueren AO,Shalaby T,Hartmann W,Warmuth-Metz M,Emser A,Kortmann RD,Kuehl J,Pietsch T,Rutkowski S

更新日期：2007-11-01 00:00:00

abstract：:Oncological diseases in children and adolescents represent a considerable burden for the children themselves and for their families. In order to position such concomitants of a life-threatening disease appropriately among the diagnostic options of psychosocial cancer care one is repeatedly confronted with the issue of...

journal_title：Klinische Padiatrie

authors： Schreiber-Gollwitzer B,Gollwitzer K

更新日期：2007-11-01 00:00:00